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. 2020 Oct;8(20):1296. doi: 10.21037/atm-20-5856

Figure 2.

Figure 2

miR-103a-3p alleviated LPS-induced oxidative stress and apoptosis in BV2 glial cells by targeting HMGB1. (A) The results predicted by TargetScan search software. (B) The ratio of R/F obtained from the luciferase activity experiment. (C,D) Effects of miR-103a-3p overexpression on the rate of cell apoptosis. (E,F) Effects of miR-103a-3p overexpression on MDA and SOD content. (G) Effects of HMGB1 interference on HMGB1 expression in OGD-stimulated BV2 microglial cells. (H,I) Effects of HMGB1 interference on MDA and SOD contents in OGD-stimulated BV2 microglial cells. (J) Effects of HMGB1 overexpression on HMGB1 expression in OGD-stimulated BV2 microglial cells. (K,L) Effects of miR-103a-3p and HMGB1 overexpression on the rate of cell apoptosis in OGD-stimulated BV2 microglial cells. (M,N) Effects of miR-103a-3p and HMGB1 overexpression on MDA and SOD content in OGD-stimulated BV2 microglial cells (**, P<0.01 versus the control group; ##, P<0.01 versus the miR-103a-3p NC group; &&, P<0.01 versus the miR-103a-3p mimic group). MDA, malondialdehyde; SOD, superoxide dismutase; HMGB1, high mobility group box 1; OGD, oxygen-glucose deprivation.