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. 2020 Oct;8(20):1296. doi: 10.21037/atm-20-5856

Figure 5.

Figure 5

miR-103a-3p alleviated oxidative stress, apoptosis, and immune disorder in rats with CI/R by targeting HMGB1. (A) Typical images of TUNEL assay and the rate of cell apoptosis (scale bar =100 µm). (B,C) Effects of miR-103a-3p overexpression on HMGB1 expression in vivo. (D) Effects of miR-103a-3p overexpression on MDA and SOD content in vivo. (E) Effects of miR-103a-3p overexpression on the levels of TNF-α, IL-1β, IL-4 and IL-10 expression in vivo (**, P<0.01 versus the control group; ##, P<0.01 versus the CI/R group). CI/R, cerebral ischemia-reperfusion injury; HMGB1, high mobility group box 1; TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling; MDA, malondialdehyde; SOD, superoxide dismutase; TNF-α, tumor necrosis factor-alpha; IL-1β, interleukin-1beta; IL-4, interleukin-4; IL-10, interleukin-10.