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Sorafenib can also decrease MGMT expression in hepatocellular carcinoma cells. Protein expression levels of MGMT, p-ERK1/2 and ERK1/2 were detected when HepG2 cells were treated with TMZ (1 mM) and Sorafenib (2, 4 and 8 µM) for 8 h by western blot analysis (*, P<0.05, **, P<0.01 vs. the indicated treatment). TMZ, temozolomide; MGMT, methylguanine-DNA methyltransferase.
