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HDAC2 deficiency facilitated M2 macrophage polarization in vitro. M2 polarization of BMDMs was induced by 10 ng/mL GM-CSF and IL-4 following treatment with 100 µg/mL PM2.5. (A) Representative FACS plots of M2 macrophages. (B) The mRNA expression level of the M2 macrophage marker Arg-1. **, P<0.01. HDAC2, histone deacetylase 2; BMDMs, bone marrow-derived macrophages; GM-CSF, granulocyte-macrophage colony-stimulating factor; IL, interleukin; PM2.5, fine particulate matter.
