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HDAC2 deficiency led to worsened lung histomorphology in a PM2.5-induced COPD model. H&E staining of lung tissue (100× magnification) shows enlargement of the alveolar space, alveolar wall destruction, and airway remodeling, as well as inflammatory cell infiltration. PM2.5, fine particulate matter; HDAC2, histone deacetylase 2; COPD, chronic obstructive pulmonary disease.
