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HDAC2 deficiency facilitated M2 macrophage polarization in a PM2.5-induced COPD model. (A) Representative FACS plots of M2 macrophages. (B) A statistical graph of FACS results. (C) The mRNA expression levels of MMP-9, MMP-12, and TGF-β1. **, P<0.01; ***, P<0.001. HDAC2, histone deacetylase 2; PM2.5, fine particulate matter; COPD, chronic obstructive pulmonary disease; FACS, fluorescence-activated cell sorting.
