Table 7.

Individual abilities of the eight different biomarkers in discriminating patients with complete and incomplete recovery without head imaging abnormalities sorted by partial area under the curve of the receiver operating characteristic (all, n = 55; complete recovery, n = 32; incomplete recovery, n = 23).

Biomarker	Threshold, pg/ml	% pAUC (95% CI)	% Specificity (95% CI)	% Sensitivity (95% CI)
NF-L	4.9	0.9 (0.0–2.9)	17.4 (4.3–34.8)	93.8 (84.4–100)
Aβ40	4.3	0.5 (0.0–2.6)	4.3 (0.0–13.0)	100 (100–100)
IL-10	8.0	0.4 (0.0–1.7)	4.3 (0.0–13.0)	100 (100–100)
GFAP	–	0.2 (0.0–1.3)	0.0 (0.0–0.0)	100 (100–100)
H-FABP	–	0.2 (0.0–2.8)	0.0 (0.0–0.0)	100 (100–100)
Aβ42	–	0.0 (0.0–2.4)	0.0 (0.0–0.0)	100 (100–100)
S100B	–	0.0 (0.0–1.1)	0.0 (0.0–0.0)	100 (100–100)
t-tau	–	0.0 (0.0–3.9)	0.0 (0.0–0.0)	100 (100–100)

Threshold indicates a level that needs to be exceeded to detect incomplete recovery. Statistically significant p-values are in bold. Mann U, Mann–Whitney U-test; pAUC, partial area under the curve of the receiver operating characteristic; Aβ40, β-Amyloid isoform 1–40; Aβ42, β-Amyloid isoform 1–42; GFAP, glial fibrillary acidic protein; H-FABP, heart fatty acid-binding protein; IL-10, interleukin 10; NF-L, neurofilament light; S100B, S100 calcium-binding protein B; t-tau, total tau.