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. 2020 Oct 30;8:588922. doi: 10.3389/fbioe.2020.588922

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Copyright © 2020 Ramos-Gomes, Ferreira, Kraupner, Alves and Markus.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ba-NPs barely penetrate the tumor capsule due to poor tumor vascularization. Confocal images of a lung lobe from a mouse with A549-mCherry induced lung tumor nodules that received Ba-Atto488 NPs i.v. shortly before sacrifice. Images show the overlay (merged) of Lectin-A647 for blood vessel staining (red), Ba-Atto488 NPs (green), and A549-mCherry positive nodules (yellow). Scale bar represents 70 μm.