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. 2020 Oct 30;8:588922. doi: 10.3389/fbioe.2020.588922

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Copyright © 2020 Ramos-Gomes, Ferreira, Kraupner, Alves and Markus.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Penetration of Ba-Atto488-NPs into the tumor tissue. Representative confocal images of a lung lobe from a Nu/Nu mouse with A549-mCherry (yellow) lung tumor nodules. Lectin-A647 (red) for blood vessel staining and Ba-Atto488 NPs (green) were injected i.v. shortly before sacrifice. (A) Overview of two tumor nodules in the lung with central necrotic areas and poor vascularization. Images show the overlay (merged) of Lectin-A647 (red), Ba-Atto488 NPs (green), and A549-mCherry cells (yellow). Scale bar represents 500 μm. (B) shows a magnified region at the border of the tumor represented in (A), with a leaky vessel within one of the nodules and Ba-Atto488-NPs that entered the surrounding tumor tissue in close proximity to the vessel. Ba-Atto488 NPs were detected with Airyscan technology. Scale bar represents 30 μm.