Fig. 7.

FGF2 alleviates the inflammation and vascular leakage in sepsis. FGF2 reduces vascular leakage caused by relieving inflammation through AKT/P38/NF-κB pathways. a LPS combined with TLR4 activates AKT/P38/NF-κB pathways to release amount of inflammatory factors leading to VE-cadherin/α-E-catenin disruption and endothelial cell barrier malfunction. b FGF2 enhances vascular barrier function against inflammatory factors production by inactivating AKT/P38/NF-κB pathways and stabilizing VE-cadherin/α-E-catenin at the cell surface