Table 1.
Estimates that are characterized by human data are marked with a superscript H, while estimates based on murine data are marked with a superscript M.
| Parameter | Description | Estimate | Reference |
|---|---|---|---|
| dp | Peptide decay rate V | 6.16/day | (21) |
| kP | Mature DC uptake rate HV | 3 × 10−2 (k/μL)-1/day | (22) |
| kPi | Immature DC uptake rate MV | 6.84 × 10−2 (k/μL)-/day | (23) |
| kPϕ | Vaccine clearance rate due to tissue macrophages MV | 3.1875/day | (24) |
| δD | Immature DC decay rate HV | 5 × 10−2/day | (25) |
| SD | Immature DC supply rate | δDI (0) | Steady state |
| I(0) | Immature DC concentration | 5.9976 k/μL | (26) |
| dA | Adjuvant washout rate M | 0.396/day | (27) |
| kS | Semi-matured/tolerized DC maturation rate | 5 × 106/day | Estimate |
| A 0 | Adjuvant saturation constant | 104 ng/mL | Estimate |
| dD | Mature DC decay rate HV | 0.33/day | (25) |
| χ | Concentration of non-vaccine-associated proteins H | 7 × 107 ng/mL | (28) |
| kD | Mature DC presentation rate MV | 2.4 × 105 pMHCs/day | (29, 30) |
| dm | pMHC degradation rate MV | 2.9/day | (31) |
| N | (Computational) maximum number of vaccine-associated pMHCs on a maturing DC | 700 | (16) |
| J | Number of avidity levels | 20 | (16) |
| dNN(0) | Naive CTL supply rate | Steady state | |
| SH | Naive helper T cell supply rate | dNHNH(0) | Steady state |
| SR | Naive nTreg supply rate | dNRNR(0) | Steady state |
| dN | Naive CTL egress rate M | 1.2/day | (32) |
| dNH | Naive helper T cell egress rate M | 2.2/day | (32) |
| dNR | Naive nTreg turnover rate M | 2.2 × 10-3/day | (33) |
| N(0) | Initial naive CTL concentration M | 7.6 × 10-3 k/μL | (34–37) |
| NH(0) | Initial naive helper T cell concentration M | 0.0571 k/μL | (34, 38) |
| NR(0) | Initial naive nTreg concentration M | 0.05 × NH(0) | (39) |
| R LH | Ratio of low-high avidity naive CTLs | 100 | Assumption |
| nR | Number of nTreg divisions HV | 6 | (40) |
| k DC | Naive CTL-DC interaction rate M | 0.4 (k/μL)-1/day | (34) |
| τm | DC migration time M | 0.75 days | (34) |
| V tissue | Volume of tissue site | 1000 μL | (16) |
| V LN | Volume of lymph node M | 4.2 μL | (34) |
| nH | Number of helper T cell divisions HV | 10 | (41) |
| τa | T cell division time M | 1 day | (38, 42) |
| dH | Effector helper T cell decay rate H | 0.008/day | (43) |
| nT | Number of CTL divisions M | 15 | (42, 44–47) |
| dT | Effector CTL decay rate H | 0.009/day | (43) |
| φ0 | Antigen saturation constant | 5 × 103 ng/mL | (16) |
| r 1 | Secretion rate of growth signal by CTLs | 0.1/day | (16) |
| r 2 | Secretion rate of growth signal by helper T cells | 1/day | (16) |
| dG | Growth factor decay rate H | 144.4/day | (48) |
| kG | T cell-growth factor interaction rate | 0.1 (k/μL)-1/day | (16) |
| kR | iTreg differentiation rate | 0.2/day | (16) |
| dR | iTreg decay rate H | 0.083/day | (49, 50) |
| dRN | Effector nTreg decay rate H | 0.063/day | (50) |
| μ | CTL-Treg interaction rate H | 5 (k/μL)-1/day | (16) |
| K | (Computational) maximum number of cognate pMHCs expressed on cancer cell | 295 | (16) |
| γ | Growth rate of melanomas H | 0.0185/day | (51–53) |
| κ | Carrying capacity of melanomas M | 736 k/μL | (54) |
| α | pMHC regeneration rate MV | 8.4/day | (55, 56) |
| kT | Tumor-CTL interaction rate HV | 16.1 (k/μL)-1/day | Estimate |
| pT | Probability of trogocytosis HV | 0.7 | Estimate |
| ω 1 | Lysis likelihood for lowest avidity (j = 1) CTL HV | 0.28 | Estimate |
| ωj | Lysis likelihood for highest avidity (j = J) CTL HV | 0.96 | Estimate |
| C init | Initial cancer concentration | 0.05 k/μL | (16, 18) |
Additionally, estimates that are based on cell culture data are marked with a superscript V. Finally, the unit ‘k’ denotes 103 cells.