Table 2.

Spearman’s rank correlation coefficient between modified model parameters and fold decreases of simulations when varied simultaneously.

Parameter	Description	Range	SRCC
dp	Peptide decay rate	± 50%	0.0575
kp	Mature DC uptake rate	± 50%	0.0283
kPi	Immature DC uptake rate	± 50%	-0.0825
kPϕ	Clearance rate due to splenic macrophages	± 50%	-0.0342
kD	Mature DC presentation rate	± 50%	-0.0274
χ	Concentration of non-vaccine-associated proteins	± 50%	-0.0530
δD	Immature DC decay rate	± 50%	0.0198
dA	Adjuvant washout rate	± 50%	0.1015
dD	Mature DC decay rate	± 50%	0.0989
kS	Semi-matured/tolerized DC maturation rate	± 50%	0.0505
dm	pMHC degradation rate	± 50%	-0.0322
dN	Naive CTL egress rate	± 50%	-0.1761
dNH	Naive helper T cell egress rate	± 50%	-0.0490
dNR	Naive nTreg turnover rate	± 50%	-0.0285
τm	DC migration time	± 50%	0.0717
kDC	Naive CTL-DC interaction rate	± 50%	-0.1214
V tissue	Volume of tissue site	± 50%	0.0427
V LN	Volume of lymph node	± 50%	-0.0591
R LH	Ratio of low-high avidity naive CTLs	10-500	-0.0630
τa	T cell division time	± 50%	0.0536
Φ 0	Antigen saturation constant	± 50%	-0.0239
nT	Number of CTL divisions	10-20	0.4981
nH	Number of helper T cell divisions	4-10	-0.0036
nR	Number of nTreg divisions	± 50%	-0.2096
dR	iTreg decay rate	± 50%	0.0907
dRN	Effector nTreg decay rate	± 50%	-0.1181
dT	Effector CTL decay rate	± 50%	0.0497
μ	CTL-Treg interaction rate	± 50%	-0.2410
kG	T cell-growth factor interaction rate	± 50%	-0.0841
kR	iTreg differentiation rate	± 50%	0.0951
dH	Effector helper T cell decay rate	± 50%	-0.0119
r 1	Secretion rate of growth signal by CTLs	± 50%	0.0557
r 2	Secretion rate of growth signal by helper T cells	± 50%	0.0508
dG	Growth factor decay rate	± 50%	0.0774
γ	Growth rate of melanomas	3 × 10-3 to 8.7 × 10−2/day	-0.7318
κ	Carrying capacity of melanomas	48.7 to 2360 k/μL	0.0260
α	pMHC regeneration rate	± 50%	0.0925
kT	Tumor-CTL interaction rate	± 50%	0.0998
pT	Probability of trogocytosis	± 50%	-0.1336
ω 1	Lysis likelihood for lowest avidity (j = 1) CTL	± 50%	0.0588