Table 3.
Summarization of 14 studies focusing on the serological association between EBV infection and SjS.
| Study | Country | Participants | Detection method | EBV antibodies |
|---|---|---|---|---|
| Venables PJ 1985 (22) | UK | 26 SjS patients and 26 healthy controls | Indirect IF | IgG-anti-VCA antibody |
| Yamaoka K 1988 (33) | Japan | 26 SjS patients and 15 healthy controls | Indirect IF | IgG-anti-VCA and IgM-anti-VCA antibodies |
| Venables PJ 1989 (25) | UK | 20 SjS patients and 35 healthy controls | ELISA | IgG-anti-EBNA1 antibody |
| Inoue N 1991 (23) | Japan | 32 SjS patients and 38 healthy controls | ELISA | IgG-anti-EBNA1 antibody |
| Yang J 1991 (34) | China | 95 SjS patients and 8 healthy controls | Indirect IF | IgG-anti-VCA, IgM-anti-VCA and IgG-anti-EBNA1 antibodies |
| Marchini B 1994 (24) | Italy | 12 SjS patients and 20 healthy controls | ELISA | IgG-anti-EBNA1 antibody |
| Toda I 1994 (26) | Japan | 62 SjS patients and 47 healthy controls | Indirect IF | IgG-anti-VCA, IgG-anti-EA, and IgG-anti-EBNA1 antibodies |
| Gao C 2010 (35) | China | 29 SjS patients and 44 healthy controls | ELISA | IgM-anti-VCA, IgG-anti-VCA and IgG-anti-EA antibodies |
| Li H 2014 (36) | China | 75 SjS patients and 74 healthy controls | ELISA | IgM-anti-VCA, IgG-anti-VCA and IgG-anti-EA antibodies |
| Yang L 2015 (37) | China | 39 SjS patients and 22 healthy controls | ELISA | IgG-anti-EBNA1 antibody |
| Zhang L 2019 (38) | China | 72 SjS patients and 60 healthy controls | ELISA | IgM-anti-VCA, IgG-anti-VCA, IgG-anti-EA and IgG-anti-EBNA1 antibodies |
| Pasoto SG 2013 (27) | Brazil | 100 SjS patients and 89 healthy controls | ELISA | IgM-anti-VCA, IgG-anti-VCA, IgG-anti-EA and IgG-anti-EBNA1 antibodies |
| Kivity S 2014 (28) | Israel | 82 SjS patients and 139 healthy controls | Multiplexed assay | IgM-anti-VCA, IgG-anti-VCA, IgG-anti-EA and IgG-anti-EBNA1 antibodies |
| Present study | China | 119 SjS patients and 65 healthy controls | ELISA | IgM-anti-VCA, IgG-anti-VCA, IgG-anti-EA and IgG-anti-EBNA1 antibodies |
IF, immunofluorescence; ELISA, enzyme linked immunosorbent assay; SjS, Sjögren’s syndrome; VCA, viral capsid antigen; EA, early antigen; EBNA1, EBV nuclear antigen 1.