Figure 3.

Pharmacological treatments modify breathing rate during acute hypoxia. “Declined breathing rate” (between 10 and 15 min after the onset of hypoxia) data is presented for 129B6F1 mice treated with saline and various concentrations of the indicated drugs 1 h before exposure to hypoxia. Values indicate mean +/– S.E.M. *p < 0.05 effect of drug vs. saline on breathing rate within genotype (black-WT, orange-NULL). +p < 0.05 effect of genotype within the indicated drug and dose. p-values determined by ANOVA with Bonferroni post-hoc correction for 61 multiple comparisons (40 for effect of drug vs. saline and 21 for effect of genotype at each drug and dose). Number of animals in each group is presented in Table 3.