Table 1.
Baseline and hypoxic breathing parameters in Mecp2 mutant mice grouped by age, strain, and sex.
| Strain | Sex | Age | Genotype | N | Baseline BPM∧ | 10% O2 Peak BPM | 10% O2 Declined BPM+∧ |
|---|---|---|---|---|---|---|---|
| 129B6F1 | Male | 3 wk | WT | 13 | 255.54 ± 32.81 | 479.08 ± 98.78 | 229.14 ± 41.36 |
| NULL | 12 | 243.19 ± 25.73 | 460.82 ± 45.18 | 213.75 ± 74.83 | |||
| 4 wk | WT | 8 | 240.74 ± 12.71 | 494.00 ± 61.13 | 243.96 ± 24.03 | ||
| NULL | 8 | 271.32 ± 20.82* | 447.55 ± 33.48 | 308.58 ± 53.47* | |||
| 5 wk | WT | 7 | 237.05 ± 10.10 | 504.73 ± 59.67 | 258.04 ± 39.14 | ||
| NULL | 6 | 260.22 ± 18.58* | 470.79 ± 36.29 | 399.10 ± 36.11* | |||
| 129B6F1 | Female | 2 yr | WT | 7 | 240.39 ± 17.65 | 484.56 ± 46.72 | 255.87 ± 28.50 |
| HET | 8 | 296.92 ± 38.55* | 430.07 ± 35.58* | 299.59 ± 16.36* | |||
| C57BL/6J | Male | 2 mo | WT | 10 | 279.24 ± 68.88 | 585.32 ± 32.56 | 233.01 ± 22.71 |
| NULL | 11 | 287.00 ± 32.96 | 516.48 ± 91.96* | 318.92 ± 77.95* |
Mean breath per minute (BPM) values are presented, +/– SD. *p < 0.05 effect of genotype (within each age, strain, and sex group). +p < 0.05 effect of age (Male 129B6F1 only). ∧p < 0.05 effect of age*genotype (Male 129B6F1 only) as determined by ANOVA. Additional parameters including Irregularity Score, Apnea Index, and uncompensated Tidal Volume were also quantified (Supplementary Table 1). Representative plethysmography traces are available (Supplementary Figure 1).