Table 3.
List of in vivo visualization of specific molecules that do not yet have inhibitors under evaluation in clinical trials.
| Molecule | Article | Utilized imaging probes | Imaging modality | Model for test | Key details of study |
|---|---|---|---|---|---|
| CD133 | Gaedicke et al. (80) | 64Cu-NOTA-AC133 mAb | MicroPET | Orthotopic glioma xenografts (subcutaneous) | Monitoring of AC133(+) glioblastoma stem cells |
| Jing H et al. (81) | IR700-AC133 mAb | NIRF | Orthotopic gliomas (subcutaneous) | Non-invasive detection of AC133 and linked with photoimmunotherapy | |
| ELTD1 | Towner et al. (134) | Anti-ELTD1 SPIO-based probe | Molecular MRI | F98 (orthotopic in rat) | Signal correlated with grade and survival |
CD133, promonin-1; ELTD1, epidermal growth factor, latrophilin, and 7 transmembrane domain-containing protein 1 on chromosome 1; F98, rat GBM cell line; mAb, monoclonal antibody; NIRF, near-infrared fluorescence; NOTA, 1,4,7-triazacyclononane-1,4,7-triacetic acid; PET, positron emission tomography; SPIO, superparamagnetic iron oxide.