TABLE 1.
Sample characteristics, overall and stratified by race.
| Characteristic | Overall sample | Non-Latino Black participants | Non-Latino white participants | p-value |
| N | 86 | 39 | 47 | |
| Age, years | 69.03 ± 6.65 (60–89) | 69.00 ± 6.61 (60–89) | 69.06 ± 6.75 (60–85) | 0.965 |
| Female, % | 50.0 | 51.3 | 48.9 | 0.831 |
| Degree years of education | 15.58 ± 2.67 (10–22) | 14.85 ± 2.50 (10–18) | 16.19 ± 2.68 (12–22) | 0.019 |
| pVIQ derived from Word Reading | 107.98 ± 11.92 (79–126) | 99.13 ± 7.92 (81–110) | 115.32 ± 9.46 (79–126) | <0.001 |
| HAM-D total | 1.08 ± 1.43 (0–7) | 1.06 ± 1.75 (0–7) | 1.09 ± 1.15 (0–4) | 0.923 |
| MMSE total | 28.79 ± 1.35 (25–30) | 28.59 ± 1.45 (25–30) | 28.96 ± 1.27 (25–30) | 0.212 |
| FSRP-10 | 6.69 ± 5.13 (1.08–26.28) | 7.09 ± 5.45 (1.76–26.28) | 6.35 ± 4.87 (1.08–17.49) | 0.510 |
| IL-6, pg/mL | 3.94 ± 2.41 (0.87–10.33) | 4.37 ± 2.33 (0.87–9.85) | 3.57 ± 2.45 (0.91–10.33) | 0.127 |
| CRP, pg/mL | 2.97 ± 1.76 (0.23–6.02) | 3.23 ± 1.84 (0.23–6.02) | 2.76 ± 1.67 (0.24–6.02) | 0.216 |
| IL1-β, pg/mL | 0.58 ± 0.12 (0.48–1.45) | 0.56 ± 0.05 (0.50–0.68) | 0.59 ± 0.15 (0.49–1.45) | 0.372 |
| Global cognition | 0.08 ± 0.62 (−1.81 to 1.55) | −0.16 ± 0.64 (−1.81 to 1.55) | 0.28 ± 0.52 (−1.21 to 1.17) | 0.001 |
| WMH (log-transformed) | 3.33 ± 0.47 (2.35–4.33) | 3.39 ± 0.41 (2.42–4.28) | 3.28 ± 0.51 (2.35–4.33) | 0.322 |
| FA/NAWM Ratio* | 2.70 ± 0.16 (2.32–3.14) | 2.66 ± 0.17 (2.32–2.97) | 2.72 ± 0.14 (2.39–3.14) | 0.123 |
| MD/NAWM Ratio* | 0.09 ± 0.03 (0.02–0.16) | 0.08 ± 0.03 (0.02–0.14) | 0.10 ± 0.03 (0.04–0.16) | 0.057 |
| MWF/NAWM Ratio* | 1.01 ± 0.06 (0.86–1.19) | 1.00 ± 0.06 (0.86–1.13) | 1.02 ± 0.06 (0.88–1.19) | 0.193 |
Values are Mean ± SD (Range) unless otherwise stated. *Indicates multiplied by factor of 1,000,000. pVIQ, predicted verbal intelligence quotient derived from Word Reading, i.e., the Wechsler Test of Adult Reading; HAM-D, Hamilton Depression Rating Scale; MMSE, Mini Mental State Examination; FSRP-10, Framingham Stroke Risk Profile 10 year percent risk of stroke; IL-6, Interleukin-6; CRP, C-reactive protein; IL1-β, Interleukin 1-beta; pg/mL, picograms per milliliter; WMH, white matter hyperintensities; FA, fractional anisotropy; MD, mean diffusivity; MWF, myelin water fraction; NAWM, normal appearing white matter. Bolded entries indicate significance at or below a p-value of 0.05.