TABLE 4.
White matter metric | β (SE) | t-value | p-value | partial η 2 |
IL-6 | ||||
White Matter Hyperintensities | 0.012(0.181) | 0.066 | 0.948 | < 0.001 |
Fractional Anisotropy | −0.005(0.072) | –0.063 | 0.950 | < 0.001 |
Mean Diffusivity | 0.006(0.013) | 0.455 | 0.650 | 0.003 |
Myelin Water Fraction | −0.003(0.028) | –0.095 | 0.925 | < 0.001 |
CRP | ||||
White Matter Hyperintensities | −0.018(0.029) | –0.643 | 0.522 | 0.006 |
Fractional Anisotropy | −0.022 (0.011) | −1.983 | 0.052 | 0.059 |
Mean Diffusivity | 0.0001(0.002) | 0.038 | 0.970 | < 0.001 |
Myelin Water Fraction | −0.009 (0.004) | −2.094 | 0.040 | 0.064 |
IL1-β | ||||
White Matter Hyperintensities | −1.753(1.044) | –1.680 | 0.098 | 0.044 |
Fractional Anisotropy | 0.339(0.408) | 0.833 | 0.408 | 0.011 |
Mean Diffusivity | 0.066(0.071) | 0.933 | 0.354 | 0.014 |
Myelin Water Fraction | 0.080(0.157) | 0.507 | 0.614 | 0.004 |
IL-6, Interleukin-6; CRP, C-reactive protein; IL1-β, Interleukin 1-beta. Bolded entries indicate significance at or below a p-value of 0.05 after adjustment for age, sex, predicted verbal IQ derived from word reading scores from the Wechsler Test of Adult Reading, race, and the Framingham Stroke Risk Profile 10 year percent risk of stroke.