Skip to main content
. 2020 Oct 30;12:553998. doi: 10.3389/fnagi.2020.553998

TABLE 4.

Associations between inflammatory markers and white matter metrics in the overall sample.

White matter metric β (SE) t-value p-value partial η 2
IL-6
 White Matter Hyperintensities 0.012(0.181) 0.066 0.948 < 0.001
 Fractional Anisotropy −0.005(0.072) –0.063 0.950 < 0.001
 Mean Diffusivity 0.006(0.013) 0.455 0.650 0.003
 Myelin Water Fraction −0.003(0.028) –0.095 0.925 < 0.001
CRP
 White Matter Hyperintensities −0.018(0.029) –0.643 0.522 0.006
 Fractional Anisotropy −0.022 (0.011) −1.983 0.052 0.059
 Mean Diffusivity 0.0001(0.002) 0.038 0.970 < 0.001
Myelin Water Fraction 0.009 (0.004) 2.094 0.040 0.064
IL1-β
 White Matter Hyperintensities −1.753(1.044) –1.680 0.098 0.044
 Fractional Anisotropy 0.339(0.408) 0.833 0.408 0.011
 Mean Diffusivity 0.066(0.071) 0.933 0.354 0.014
 Myelin Water Fraction 0.080(0.157) 0.507 0.614 0.004

IL-6, Interleukin-6; CRP, C-reactive protein; IL1-β, Interleukin 1-beta. Bolded entries indicate significance at or below a p-value of 0.05 after adjustment for age, sex, predicted verbal IQ derived from word reading scores from the Wechsler Test of Adult Reading, race, and the Framingham Stroke Risk Profile 10 year percent risk of stroke.