Table 3.
Risk factors for mortality in patients with COVID-19 receiving respiratory support
| Variable | Univariate | Multivariate analysis | |
| P value* | P value* | HR (95% CI) | |
| Age, years | <0.001 | <0.001 | 1.054 (1.028 to 1.082) |
| Male (yes/no) | 0.014 | ||
| Comorbidities (yes/no) | |||
| Hypertension | 0.392 | ||
| Diabetes | 0.001 | 0.002 | 2.226 (1.357 to 3.652) |
| Chronic obstructive pulmonary disease | 0.009 | ||
| Chronic kidney disease | 0.841 | ||
| Chronic liver disease | 0.226 | ||
| ACE inhibitor/ARB use (yes/no) | 0.871 | ||
| Lymphocyte count, ×103/uL | <0.001 | 0.005 | 0.999 (0.998 to 1.000) |
| Platelet count, ×109/L | 0.087 | 0.069 | 0.997 (0.994 to 1.000) |
| C reactive protein, mg/L | 0.584 | ||
| Aspartate aminotransferase, U/L | 0.050 | 0.033 | 1.002 (1.000 to 1.003) |
| Alanine aminotransferase, U/L | 0.552 | ||
| Total bilirubin, mg/dL | 0.831 | ||
| Alkaline phosphatase, U/L | 0.725 | ||
| Gamma glutamyl transferase, U/L | 0.263 | ||
| Serum albumin, g/dL | 0.773 | ||
| Prothrombin time, INR | 0.444 | ||
| Estimated glomerular filtration rate, mL/min/1.73 m2 | 0.002 | ||
| SIRS on admission (yes/no) | <0.001 | 0.074 | 1.968 (1.199 to 3.230) |
*Calculated by Cox proportional hazards regression test.
ARB, angiotensin II receptor blocker; INR, international normalised ratio; SIRS, systemic inflammatory response syndrome.