Table 3.

Results of Univariate Mixed Models for Each of the Predictor Variables in the Total Sample, Adjusted for Baseline Age, Sex, Education, and Test Version

	Cross-sectional	Predictor × Time
	β (95% CI); p-Value	β (95% CI); p-Value
Age	−0.109 (−0.122 to −0.096); <.001	−0.012 (−0.014 to −0.01); <.001
Female	0.801 (0.554 to 1.048); <.001	0.011 (−0.025 to 0.046); .553
Years of education	0.04 (0.011 to 0.07); .008	0.003 (−0.001 to 0.007); .212
Manufacturing profession	−0.174 (−0.503 to 0.156); .302	−0.058 (−0.104 to −0.012); .014
Vocabulary (SRB1)	0.069 (0.04 to 0.097); <.001	0.004 (0.001 to 0.008); .026
History of cerebrovascular disease	−0.056 (−0.532 to 0.419); .816	−0.127 (−0.206 to −0.047); .002
Cardiovascular disease burden	−0.103 (−0.294 to 0.089); .294	−0.057 (−0.087 to −0.026); <.001
Diabetes	−0.173 (−0.625 to 0.279); .454	−0.114 (−0.182 to −0.047); .001
Hypertension stage 2	0.185 (−0.619 to 0.433); .142	−0.027 (−0.061 to 0.008); .129
Obesity	−0.133 (−0.486 to 0.220); .460	0.03 (−0.02 to 0.081); .234
Smoking (previously)	−0.165 (−0.425 to 0.096); .215	0.012 (−0.025 to 0.049); .517
Smoking (currently)	−0.344 (−0.723 to 0.035); .076	−0.011 (−0.066 to 0.043); .679
History of head trauma	−0.305 (−0.659 to 0.049); .092	−0.011 (−0.061 to 0.039); .647
Depression	−0.821 (−1.513 to −0.13); .02	−0.031 (−0.14 to 0.078); .577
Number of medications	−0.004 (−0.044 to 0.037); .863	−0.009 (−0.015 to −0.003); .002
Walking speed	0.589 (0.188 to 0.99); .004	0.127 (0.075 to 0.179); <.001
APOE ε4 carrier	−0.31 (−0.577 to −0.044); .023	−0.057 (−0.095 to −0.019); .003
BDNF met carrier	0.256 (0.001 to 0.511); .049	−0.028 (−0.065 to 0.01); .146