Table 1.

Summary of MICs and known β-lactamase gene content for isolates selected for the in vivo efficacy studies

Isolate	MIC (mg/L)		β-Lactamase(s) encoded
	cefepime	cefepime + taniborbactam (4 mg/L)
EC 481	>512	0.125	CTX-M-15
ECL 96	>512	8	TEM-OSBL; CTX-M-15; ACT-7
ECL 123	>512	0.5	TEM-OSBL; CTX-M-15; ACT-New Variant; OXA-48
ECL 124	>512	8	TEM-OSBL; CTX-M-15; ACT-7
KP 329B	512	0.25	SHV-11; SHV-5; OXA-9; KPC-2; TEM-1
KP 510	256	0.06	CTX-M-11; SHV-11; DHA-1; TEM-1A
KP 569	>512	4	OXA-48; CTX-M-15
KP 575	>512	2	KPC
KP 579	>512	16	SHV-11; TEM-1; CTX-M-15; OXA-48
KP 580	>512	8	SHV-OSBL; TEM-OSBL; CTX-M-15; OXA-48
KP 583	>512	4	SHV-32; TEM-1; CTX-M-15; OXA-48
KP 585	512	8	KPC
KP 679	>512	4	OXA-232; OXA-9; TEM-1A; CTX-M-15; OXA-1
KP 686	>512	1	KPC-3; OXA-9; TEM-1A; SHV-11
KP 731	>512	1	SHV-11; TEM-1; KPC-3
KP 732	>512	1	SHV-OSBL; TEM-OSBL; KPC-2
KP 734	>512	2	KPC-3
KP 735	>512	2	KPC-2
KP 736	>512	1	SHV-11; CTX-M-55; OXA-48
KP 737	>512	2	SHV-OSBL; CTX-M-15; OXA-48
KP 738	>512	4	KPC-3
KP 739	>512	8	SHV-11; TEM-1; CTX-M-15; OXA-48
KP 740	>512	8	SHV-OSBL; TEM-OSBL; CTX-M-15; OXA-48
KP 742	>512	8	SHV-11; TEM-1; CTX-M-15; OXA-48
KP 743	>512	8	SHV-11; TEM-1; CTX-M-15; OXA-48
KP 744	>512	4	SHV-32; TEM-1; CTX-M-15; OXA-48
PSA 1593	>512	4	KPC
PSA 1672	>512	2	AmpC overexpression
PSA 1675	32	2	AmpC overexpression
PSA 1676	32	1	AmpC overexpression
PSA 1677	32	2	AmpC overexpression
PSA 1679	256	16	AmpC overexpression
PSA 1680	32	4	AmpC overexpression
PSA 1681	>512	8	AmpC overexpression
PSA 1684	64	16	AmpC overexpression
PSA JJ8-16	32	4	ND
PSA JJ11-54	64	8	ND

ND, not determined; EC, Escherichia coli; KP, Klebsiella pneumoniae; PSA, P. aeruginosa; ECL, Enterobacter cloacae.