Table 4.

Interaction energies (ΔG) of molecules docked into the active site of HDACs isoforms.

Ligand	HDAC1 (kcal/mol)	HDAC6 (kcal/mol)	HDAC8 (kcal/mol)
SAHA	−86.16	−55.33	−20.42
7c	−89.78	−73.66	−25.20
7e	−118.77	−68.80	−31.56
7f	−111.23	−79.28	−30.17
7i	−108.99	−68.82	−29.20
7j	−113.59	−80.73	−48.89