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. 2020 Nov 3;21(21):8220. doi: 10.3390/ijms21218220

Figure 2.

Figure 2

Chronic paroxetine (20 mg/kg/day for 28 days) or amitriptyline (180 mg/L for 28 days) treatment reduces social fear in ASM+/+ and ASM+/− mice but not in ASM−/− mice. (a,d,g) Preconditioning investigation of the non-social stimulus (empty cage) shown by unconditioned (SFC−) and conditioned (SFC+) mice during SFC on day 1. (b,e,h) Number of foot shocks received by SFC+ mice during SFC. (c,f,i) Investigation of the non-social (ns1–ns3) and social (cages with mice, s1–s6) stimuli during social fear extinction on day 30. Paroxetine (Par) or amitriptyline (Ami) were administered over 28 days in the drinking water (W) starting one day after SFC. Data represent means ± SEM, and numbers in parentheses indicate group sizes. p < 0.05 * versus all groups, # versus SFC−/W and SFC+/W, and + versus SFC+/W.