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Relationship between NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome and microbiota. NLRP3 inflammasome intestinal inflammation via the microbiota. The microbiota controls intestinal inflammation via the NLRP3 inflammasome. In addition, short-chain fatty acids produced by the microbiota induce NLRP3 inflammasome activation. IL, Interleukin; NLRP3, NOD-like receptor family pyrin domain-containing 3; TNF, Tumor necrosis factor.
