NLRP3, 1, 6, 12 |
NOD-like receptor family pyrin domain-containing 3, 1, 6, 12 |
PRR |
Pattern recognition receptor |
PAMP |
Pathogen-associated molecular pattern |
DAMP |
Danger-associated molecular pattern |
CAPS |
Cryopyrin-associated periodic syndrome |
CARD |
Caspase recruitment domain |
ASC |
Apoptosis-associated speck-like protein containing a caspase recruitment domain |
IL |
Interleukin |
NLR |
NOD-like receptor |
PYD |
Pyrin domain |
IBD |
Inflammatory bowel disease |
KO |
Knockout |
TLR |
Toll-like receptor |
RLR |
Retinoic acid-inducible gene-I-like receptor |
AIM2 |
Absent in melanoma 2 |
ALR |
Absent in melanoma 2-like receptor |
PYHIN |
Pyrin and HIN domain |
NLRC4 |
NOD-like receptor family caspase recruitment domain-containing 4 |
NACHT |
Neuronal apoptosis inhibitory protein, MHC class II transcription activator, incompatibility locus protein from Podospora anserina, and telomerase-associated protein |
NAIP |
Neuronal apoptosis inhibitory protein |
CIITA |
MHC class II transcription activator |
HET-E |
Incompatibility locus protein from Podospora anserina |
TP1 |
Telomerase-associated protein |
LRR |
Leucine-rich repeat |
NAIP |
Neuronal apoptosis inhibitory protein |
IL-1R |
Interleukin-1 receptor |
NF-κB |
Nuclear factor-kappa B |
T3SS/T4SS |
Type III/IV secretion system |
MDP |
Muramyl dipeptide |
ROS |
Reactive oxygen species |
BTK |
Bruton’s tyrosine kinase |
JNK |
c-Jun N-terminal kinase |
NEK7 |
NIMA-related kinase 7 |
TAK1 |
TGF-β-activated kinase 1 |
GBP5 |
Guanylate-binding protein 5 |
CaSR |
Calcium-sensing receptor |
CD |
Crohn’s disease |
LPS |
Lipopolysaccharide |
FMF |
Familial Mediterranean fever |
UC |
Ulcerative colitis |
SNP |
Single-nucleotide polymorphism |
TNF |
Tumor necrosis factor |
Th |
T helper |
DSS |
Dextran sulfate sodium |
IFN |
Interferon |
IL-18BP |
Interleukin-18-binding protein |
NK |
Natural killer |
IEC |
Intestinal epithelial cell |
ATG |
Autophagy-related gene |
Treg |
T regulatory |
SCFA |
Short-chain fatty acid |
PBMC |
Peripheral blood mononuclear cell |
WT |
Wild type |
AOM |
Azoxymethane |
STAT |
Signal transducer and activator of transcription |
TNBS |
2,4,6-trinitrobenzene sulfonic acid |