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. 2020 Oct 30;25(21):5037. doi: 10.3390/molecules25215037

Figure 3.

Figure 3

Effect of andrographolide and andrographolide analogues on ZIKV and DENV infection. A549 (A,B), or HEK293T/17 (C,D) cells were infected with ZIKV (A,B) or DENV 2 (C,D) at MOI 5. After removal of the unbound virus, cells were treated with optimal concentrations of each compound. After 24 h of treatment, cells were harvested and analyzed for the level of infection by flow cytometry (A,C). The culture supernatants were collected to determine the viral production by standard plaque assay (B,D). The experiments were undertaken independently in triplicate with duplicate plaque assay. The error bars show mean ± standard deviation (SD) (* means p-value < 0.05, ** means p-value < 0.005 and *** means p-value < 0.001).