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. 2020 Nov 2;25(21):5087. doi: 10.3390/molecules25215087

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of baicalein, wogonin, and oroxylin A on the production of proinflammatory cytokines and their protein expressions in Aβ_25–35-induced PC12 cells. The cells were pretreated with samples for 1 h, and stimulated with Aβ_25–35 for 24 h. The media were collected to assess the production of no and PGE₂. The expression of TNF-α (a), iNOS (d), and COX-2 (e). NO levels were assessed by Griess assay (b). PGE₂ levels in supernatants were determined by ELISA assay kit (c). The PC12 cells were incubated with samples and then treated with Aβ_25–35 for 24 h. The cells were lysed and the protein levels were quantified using the BCA assay. Different alphabets indicated significant difference at p < 0.05.

Effect of baicalein, wogonin, and oroxylin A on the production of proinflammatory cytokines and their protein expressions in Aβ_25–35-induced PC12 cells. The cells were pretreated with samples for 1 h, and stimulated with Aβ_25–35 for 24 h. The media were collected to assess the production of no and PGE₂. The expression of TNF-α (a), iNOS (d), and COX-2 (e). NO levels were assessed by Griess assay (b). PGE₂ levels in supernatants were determined by ELISA assay kit (c). The PC12 cells were incubated with samples and then treated with Aβ_25–35 for 24 h. The cells were lysed and the protein levels were quantified using the BCA assay. Different alphabets indicated significant difference at p < 0.05.