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. 2020 Nov 3;21(21):8212. doi: 10.3390/ijms21218212

Figure 1.

Figure 1

(A) In experiment 1, human immunodeficiency virus (HIV)-1 trans-activator of transcription (Tat) expression was induced in Tat(+) males (hatched bars), or not induced in Tat(−) controls (open bars), via administration of doxycycline (30 mg/kg, i.p., once daily for 5 days with 2 days of washout). Mice were either stressed via forced swim for 15 min (panels (D,E)) or not (panels (B,C)) and acutely-administered saline or oxycodone (3 mg/kg, i.p.) 15 min prior to assessment in an open field and light-dark transition test (n = 8–12/group). (B) Distance (m) traveled in an open field and (C) circulating corticosterone among non-stressed mice. (D) Distance (m) traveled in an open field and (E) circulating corticosterone among stressed mice. * indicates a main effect of genotype wherein Tat(+) mice differ from Tat(−) controls. † indicates a main effect for oxycodone to differ from saline-administered mice. ˄ indicates an interaction wherein saline-administered Tat(+) mice differ from respective Tat(−) controls, p < 0.05.