Figure 4.

Au-Gd³⁺-prostate-specific membrane antigen (PSMA) NPs for MR-guided radiation therapy. (a) Schematic representation of Au-Gd³⁺-PSMA NPs. (b) TEM micrograph indicates that the average core size of Au-Gd³⁺-PSMA NPs is 5 nm, and DLS shows that the hydrodynamic diameter of Au-Gd³⁺-PSMA NPs is 7.8 nm. (c) In vivo tumor targeting of Au-Gd³⁺-PSMA NPs and MR imaging of PC3pip tumor-bearing mouse (up) and PC3flu tumor-bearing mouse (bottom) obtained at 7 T. PC3pip tumor cell expresses high level of PSMA, while PC3flu tumor cell expresses low level of PSMA (the mice were injected with Au-Gd³⁺-PSMA NPs at 60 μmol Gd³⁺⋅kg⁻¹ through the tail vein, adapted from Basilion et al. 2020 [50], Copyright 2020 The American Chemical Society and reproduced with permission).