Figure 3.

The model of the sliding of nucleosome along the DNA. According to this model, the binding of HmgB1 with H1 histone results in disruption of H1 interactions with DNA and its displacement. The loops of DNA formed by HmgB1-DNA binding are necessary for interaction of the remodeling complex (RC) with DNA. In turn, PC–DNA complex is responsible for the sliding of the nucleosome, until the transcribed region of DNA becomes available for transcription factors (TF). Next, the process of HmgB1-dependent binding of transcription factors to DNA takes place.