Figure 2.

Clinical parameters in infection with single RMS allele variant. Clinical score (A), weight change (B) and bacterial titers in cerebellum at 42 hpi (C) and CSF at 24 hpi (D) in animals infected with the 4 different hsdS allele variants (A: n = 8, B: n = 8, C: n = 8, D: n = 8). The vertical dotted lines represent separation between the different time points and the initiation of the amoxicillin treatment is indicated by an arrow under the x-axis. The variants show altered virulence measured by the clinical score, weight change and cerebellum titer. The detailed statistical analyses are provided in Supplementary Tables 1, 2. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.