Figure 3.

Inflammatory and histological parameters in infection with single RMS allele variant. Cytokine levels of IL-1β (A), IL-18 (B), and VEGF (C) measured in cerebellum homogenate at 42 hpi in infant rats infected with the 4 different hsdS allele variants (A: n = 8, B: n = 8, C: n = 8, D: n = 8). The horizontal dotted line represents the lower limit of detection, data points under the line are extrapolated measurements. The variants show different concentrations for IL-1β and VEGF. Variant D leads to higher IL-1β level, whereas variant B shows elevated VEGF levels. No significance was found for IL-18 levels. Significant difference in the level of apoptosis (D) was only found for the comparison between infection with variants A and C, while hydrocephalus (E) was not different between infection with the 4 variants. *p < 0.05; **p < 0.01; ****p < 0.0001.