Figure 7.

Change in the proportion of PV RMS alleles between the 2 variants inoculums and in vivo samples. Results were pooled from seven independent experiments and each variant is independently calculated as a percentage change from the initial inoculum for that experiment. The relative proportions of hsdS variants A (red), B (blue), C (gray) and D (white) between the inoculum and the bacteria harvested in In vivo CSF and cerebellum samples. A Kruskal-Wallis test showed that the proportion of the A variant is repeatedly reduced in comparison to the starting inoculum, while the C (CSF and brain) and B (brain) variants increase. p < 0.05 (*), p < 0.01 (**), and p < 0.0001 (****).