TABLE 1.

Lipid Nanoparticle Drug Delivery Systems (LNDDS) on currently active clinical trials (terminated or withdrawn studies were excluded).

Track number	Status	Drug	Disease	Route of administration
siRNA therapy
NCT01960348	Phase III	Patisiran (ALN-TTR02)	hTTR - mediated amyloidosis	IV infusion
NCT01858935	Phase I	ND-L02-s0201	Hepatic fibrosis	IV infusion
NCT02227459	Phase I	ND-L02-s0201	Hepatic fibrosis	IV infusion
NCT01437007	Phase I	TKM-080301	Primary liver carcinoma or metastatic liver cancer	Hepatic arterial infusion
mRNA therapy
NCT04416126	Phase I	ARCT-810	OTC deficiency	IV infusion
NCT04442347	Phase I	ARCT-810	OTC deficiency	IV infusion
NCT03323398	Phase I Phase II	mRNA-2416	Solid tumors / Lymphoma / Ovarian Cancer	Intratumoural
NCT03739931	Phase I	mRNA-2752	Solid tumor malignancies / Lymphoma	Intratumoural
NCT04283461	Phase I	mRNA-1273	COVID-19	IM injection
Others
NCT02971007	Phase II	CAMB	Vulvovaginal candidiasis	Oral
NCT02629419	Phase II	CAMB	Mucocutaneous candidiasis	Oral
NCT04148833	Phase II Phase III	Paclitaxel	Aortic and coronary atherosclerotic disease	IV injection
NCT03823040	Phase I	Oxiconazole	Tinea pedis / Tinea versicolor/Tinea circinate	SLNs loaded gel for topical application

CAMB, encochleated amphotericin B; HSP47, Heat Shock Protein; IM, intramuscular; IV, intravenous; OTC, ornithine transcarbamylase; PLK1, polo-like kinase-1; TTR, Transthyretin.