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. 2020 Oct 30;11:571049. doi: 10.3389/fimmu.2020.571049

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Copyright © 2020 Schmidt, Wenndorf, Ebbers, Volzke, Müller, Strübing, Kriebel, Kneitz, Kreikemeyer and Müller-Hilke

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Infection with Clostridioides difficile significantly reduced incidence of collagen-induced arthritis in DBA/1J × B10.Q mice. (A) Macroscopic pictures of healthy (upper row) and arthritic paws (middle row) and corresponding scoring schemes (lower row) are shown. Middle row from left to right: an arthritis score of 1 (one inflamed digit), 15 (five inflamed digits, inflamed tarsal and metatarsal joints), 1 (one inflamed digit), and 11 (one inflamed digit, inflamed tarsal and metatarsal joints) respectively. (B) inverted Kaplan-Meier plot shows incidences of collagen-induced arthritis after mice were boosted on experimental day 49. Asterisks denote an extremely significant difference between the groups at the various time points as calculated via log rank (Mantel-Cox) test. The resulting p-value was 0.000363.