Table A1.
DWI and FLAIR radiomic features with significant difference by Wilcoxon rank sum test between IDH1 Wildtype and Mutant.
| Radiomic Feature | p-Value | IDH1 Wildtype Mean ± SD | IDH1 Mutant Mean ± SD |
|---|---|---|---|
| FLAIR_Original Gray Level Run Length Matrix Short Run High Gray Level Emphasis | <0.001 | 1093.41 ± 372.49 | 1456.95 ± 376.78 |
| FLAIR_Original Gray Level Size Zone Matrix Small Area High Gray Level Emphasis | <0.001 | 635.48 ± 187.18 | 824.98 ± 1 91.8 |
| FLAIR_Original Gray Level Run Length Matrix High Gray Level Run Emphasis | <0.001 | 1201.22 ± 405.95 | 1602.17 ± 426.86 |
| FLAIR_Original Gray Level Dependence Matrix High Gray Level Emphasis | <0.001 | 1209.73 ± 412.96 | 1613.11 ± 433.94 |
| FLAIR_Original Gray Level Co-occurrence Matrix Cluster Shade | 0.001 | −167.45 ± 1997.12 | −2819.29 ± 5053.17 |
| FLAIR_Original Gray Level Co-occurrence Matrix Autocorrelation | 0.001 | 1228.14 ± 426.63 | 1619.82 ± 455.56 |
| FLAIR_Original Gray Level Co-occurrence Matrix Joint Average | 0.002 | 33.81 ± 6.42 | 39.06 ± 5.76 |
| FLAIR_Original Gray Level Co-occurrence Matrix Sum Average | 0.002 | 67.62 ± 12.85 | 78.12 ± 11.52 |
| FLAIR_Original First Order Skewness | 0.003 | −0.02 ± 0.57 | −56 ± 0.67 |
| DWI_Original Gray Level Size Zone Matrix Small Area High Gray Level Emphasis | 0.005 | 546.7 ± 250.71 | 743.57 ± 287.76 |
| FLAIR_Original Gray Level Run Length Matrix Long Run High Gray Level Emphasis | 0.006 | 1997.25 ± 716.52 | 2621.33 ± 982.83 |
| DWI_Original Gray Level Run Length Matrix High Gray Level Run Emphasis | 0.007 | 831.51 ± 457.59 | 1205.94 ± 547.74 |
| DWI_Original Gray Level Run Length Matrix Short Run High Gray Level Emphasis | 0.007 | 769.52 ± 434.1 | 1119.01 ± 509.77 |
| DWI_Original Gray Level Dependence Matrix High Gray Level Emphasis | 0.007 | 825.3 ± 462.6 | 1201.58 ± 553.71 |
| FLAIR_Original Gray Level Dependence Matrix Small Dependence High Gray Level Emphasis | 0.007 | 241.62 ± 118.86 | 316.36 ± 117.92 |
| DWI_Original First Order Skewness | 0.008 | 0.46 ± 1.06 | −0.32 ± 0.9 |
| FLAIR_Original First Order Range | 0.010 | 1214.54 ± 671.87 | 989.59 ± 882 |
| DWI_Original Gray Level Run Length Matrix Long Run High Gray Level Emphasis | 0.010 | 1211.61 ± 574.88 | 1710.77 ± 768.55 |
| DWI_Original Gray Level Dependence Matrix Small Dependence High Gray Level Emphasis | 0.012 | 213.92 ± 161.61 | 312.42 ± 172.48 |
| DWI_Original Gray Level Co-occurrence Matrix Autocorrelation | 0.012 | 821.63 ± 471.38 | 1184.7 ± 570.82 |
| DWI_Original Neighboring Gray Tone Difference Matrix Busyness | 0.013 | 1.23 ± 1.02 | 0.68 ± 0.53 |
| DWI_Original First Order Maximum | 0.014 | 1174.11 ± 596.34 | 835.35 ± 453.04 |
| FLAIR_Original Neighboring Gray Tone Difference Matrix Busyness | 0.014 | 4.04 ± 3.16 | 2.17 ± 1.59 |
| DWI_Original Gray Level Co-occurrence Matrix Joint Average | 0.015 | 26.59 ± 8.64 | 32.68 ± 8.43 |
| DWI_Original Gray Level Co-occurrence Matrix Sum Average | 0.015 | 53.18 ± 17.29 | 65.35 ± 16.86 |
| DWI_Original First Order Uniformity | 0.022 | 0.05 ± 0.02 | 0.04 ± 0.01 |
| DWI_Original First Order Range | 0.023 | 1101.2 ± 596.03 | 775.94 ± 454.76 |
| DWI_Original Gray Level Dependence Matrix Gray Level Variance | 0.024 | 62.83 ± 36.88 | 78.73 ± 30.73 |
| DWI_Original Gray Level Run Length Matrix Gray Level Non Uniformity Normalized | 0.024 | 0.05 ± 0.02 | 0.04 ± 0.01 |
| DWI_Original Gray Level Run Length Matrix Gray Level Variance | 0.024 | 64.79 ± 36.43 | 80.37 ± 30.18 |
| DWI_Original Gray Level Run Length Matrix Gray Level Non Uniformity | 0.027 | 1106.8 ± 928.02 | 619.32 ± 481.82 |
| DWI_Original Gray Level Dependence Matrix Gray Level Non Uniformity | 0.031 | 1403.34 ± 1300.29 | 728.69 ± 584.29 |
| DWI_Original Neighboring Gray Tone Difference Matrix Contrast | 0.032 | 0.1 ± 0.1 | 0.14 ± 0.11 |
| DWI_Original Neighboring Gray Tone Difference Matrix Coarseness | 0.034 | 0.00 ± 0.0015 | 0.0013 ± 0.0016 |
| DWI_Original Gray Level Dependence Matrix Large Dependence High Gray Level Emphasis | 0.034 | 15,902.19 ± 7204.39 | 21,277.99 ± 11,907.81 |
| FLAIR_Original First Order Maximum | 0.036 | 1461.66 ± 783.13 | 1223.18 ± 953.74 |
| DWI_Original Gray Level Size Zone Matrix Small Area Emphasis | 0.037 | 0.59 ± 0.05 | 0.62 ± 0.05 |
| FLAIR_Original Gray Level Co-occurrence Matrix Informal Measure of Correlation 2 | 0.037 | 0.77 ± 0.09 | 0.82 ± 0.09 |
| FLAIR_Original Neighboring Gray Tone Difference Matrix Strength | 0.038 | 0.53 ± 1.08 | 0.51 ± 0.42 |
| DWI_Original Gray Level Size Zone Matrix Size Zone Non Uniformity Normalized | 0.039 | 0.33 ± 0.05 | 0.36 ± 0.05 |
| FLAIR_Original Neighboring Gray Tone Difference Matrix Coarseness | 0.039 | 0.0003 ± 0.0005 | 0.0003 ± 0.0002 |
| FLAIR_Original First Order Standard Deviation | 0.045 | 151.45 ± 77.39 | 132.06 ± 109.62 |
| FLAIR_Original First Order Variance | 0.045 | 28,850.28 ± 32,282.11 | 28,910.57 ± 43,752.27 |
| FLAIR_Original First Order Total Energy | 0.046 | 73,306,599,504.28 ± 90,074,867,196.59 | 78,905,231,446.5 ± 128,228,405,390.59 |
| DWI_Original First Order Entropy | 0.047 | 4.7 ± 0.49 | 4.95 ± 0.29 |
| DWI_Original Gray Level Size Zone Matrix Gray Level Non Uniformity Normalized | 0.047 | 0.03 ± 0.01 | 0.03 ± 0.005 |