Table 5.
Effect of fatty acids on nine CYPs: 1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2E1 and 3A4.
| Fatty Acid | Absolute IC50 (μM) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 1A2 | 2A6 | 2B6 | 2C8 | 2C9 | 2C19 | 2D6 | 2E1 | 3A4 | |
| Arachidonic acid | 9.7 | 21.4 | 4.6 | 1.3 | 3.3 | 23.2 | 18.3 | 61.7 | 11.7 |
| Behenic acid | >30 | >30 | >30 | >30 | >30 | >30 | >30 | >30 | >30 |
| Cervonic acid | 6.3 | 11.7 | 6.7 | 1.2 | 2.6 | 15.8 | 5.6 | 44.4 | 7.5 |
| Gondoic acid | 16.2 | 81.9 | 16.6 | 6.0 | 17 | >100 | >100 | >100 | >100 |
| Lauric acid | >100 | >100 | 21.5 | 42.9 | >100 | >100 | >100 | >100 | >100 |
| Linoleic acid | 13.3 | 28.9 | 7.1 | 1.0 | 7.4 | 55.8 | 17.5 | 58.9 | 18.5 |
| α-Linolenic acid | 8.8 | 13.5 | 9.7 | 4.4 | 10.6 | 53.3 | 34.3 | 67.2 | 36.9 |
| Myristic acid | 15.8 | >100 | 10.7 | 13.3 | 36.1 | >100 | >100 | >100 | >100 |
| Nervonic acid | >11.1 | >11.1 | >11.1 | >11.1 | >11.1 | >11.1 | >11.1 | >11.1 | >11.1 |
| Oleic acid | 11.2 | 25 | 8.2 | 4.4 | 5.7 | 98.9 | 18.1 | 83.8 | 11.4 |
| Palmitic acid | >100 | >100 | 90.5 | >100 | >100 | >100 | >100 | >100 | >100 |
| Palmitoleic acid | 7.8 | 36.2 | 8 | 9.7 | 11.9 | 58.1 | 30.3 | 72.1 | 26.5 |
| Stearic acid | >33.3 | >33.3 | >33.3 | >33.3 | >33.3 | >33.3 | >33.3 | >33.3 | >33.3 |
| Timnodonic acid | 8.2 | 17.4 | 5.9 | 1.5 | 3.8 | 13.8 | 5.7 | 77.4 | 16 |