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. 2020 Oct 30;11:568694. doi: 10.3389/fimmu.2020.568694

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Copyright © 2020 Teixeira, Cavenague, Kochi, Fernandes, Souza, de Souza Filho, Vasconcellos, Heinemann and Nascimento

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Total IgG production after animal immunization. Hamsters were immunized subcutaneously with emulsions of recombinant protein plus Alhydrogel, twice at 2 weeks intervals. Serum samples were obtained after 2 weeks of each immunization and IgG levels evaluated by ELISA. For experimental control, animals were immunized with phosphate-buffered saline (PBS) in Alhydrogel (control) and with heat-killed whole-leptospires (bacterin). Unpaired t-test was used to determine statistically significant difference between proteins and PBS. All of them showed significance < 0.05.