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. 2020 Oct 28;25(21):5006. doi: 10.3390/molecules25215006

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Transfection efficiency (TE) of L_α^C complexes versus cationic lipid molar fraction and membrane charge density (σ_M). The ρ_chg is fixed at 2.8 (A) The TE increases with the cationic lipid molar fraction, reaching a peak before decreasing again. The TE peak moves to smaller cationic fractions for larger cationic lipid nominal charge. (B) When the TE is replotted as a function of σ_M, the data for the different headgroup charges (+1 to +5) all collapse into a universal bell-shaped curve that can be sub-divided into three regimes. Regime II has a TE comparable to the TE of H_II^C complexes. Reproduced with permission from [193]. Copyright 2005 John Wiley & Sons Limited.