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Homology models of DLC-1 and DLC-2 START domains. (A,C) Side and (B,D) top-down views of (A,B) DLC-1 (green) and (C,D) DLC-2 (orange) START domains. Blue indicates conserved residues with missense mutations in cancers. Red indicates conserved arginine, serine, and phenylalanine residues mutated in both DLC-1 and DLC-2, as well as the highly-conserved arginine in DLC-1 (R988) mutated in numerous cancers.
