ADC |
antibody–drug conjugate |
ADCC |
antibody-dependent cellular cytotoxicity |
ADP |
antibody-dependent phagocytosis |
APC |
antigen-presenting cell |
BCMA |
B-cell maturation antigen |
belamaf |
belantamab mafodotin |
BiAb |
bispecific antibody |
BiTE |
bispecific T-cell engager |
CDC |
complement-dependent cytotoxicity |
CRS |
cytokine release syndrome |
CTLA-4 |
cytotoxic T-lymphocyte antigen 4 |
d, dex |
dexamethasone |
Dara |
daratumumab |
di-scFv |
bivalent single-chain variable fragment |
Elo |
elotuzumab |
EMA |
European Medicines Agency |
Fab |
fragment antigen binding |
Fc |
fragment crystallizable region |
FDA |
US Food and Drug Administration |
G |
grade |
Ig |
immunoglobulin |
IMiDs |
immunomodulatory drugs |
IRR |
infusion-related reaction |
Isa |
isatuximab |
iv |
intravenous |
K |
carfilzomib |
mAb |
monoclonal antibody |
MAC |
membrane attack complex |
MDSC |
myeloid-derived suppressor cell |
MM |
multiple myeloma |
MMAF |
monomethyl auristatin F |
MRD |
minimal residual disease |
NA |
not available |
NDMM |
in newly diagnosed (ND) MM |
NK |
natural killer cell |
NR |
not reached |
NTE |
non-transplant-eligible |
ORR |
overall response rate |
OS |
overall survival |
P, Poma |
pomalidomide |
PD-1 |
programmed cell death protein 1 |
PD-L1 |
programmed death ligand 1 |
PFS |
progression-free survival |
PI |
proteasome inhibitor |
R |
lenalidomide |
RRMM |
relapsed/refractory multiple myeloma |
sc |
subcutaneous |
scFv |
single-chain variable fragment |
sCR |
stringent complete response |
SLAMF7 |
signaling lymphocytic activation molecule family 7 |
T |
thalidomide |
TE |
transplant-eligible |
Treg |
regulatory T cell |
V |
bortezomib |
VMP |
bortezomib-melphalan-prednisone |