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. 2020 Oct 27;21(21):7967. doi: 10.3390/ijms21217967

Figure 2.

Figure 2

FGF-2, but not BMP-2, promotes repair of mouse femoral defect. Collagen pellets containing BMP-2 (10 µg) or FGF-2 (1 µg, 10 µg) or DW (control) were transplanted into mouse femur defects. (A) Micro-CT sagittal images of the femur (upper panel) and 3D reconstructed images of the trabecular bone (lower panel) of an area ranging from 1 mm above and below the defect. (B) Graph shows the quantitative analysis of BV/TV of an area within 1 mm above and below the defect in the femur. (n = 3–4, * p < 0.05 versus control pellet (#). One-way ANOVA/Tukey). (C) HE-staining of frontal sections at the femur defect area at 5 days and 14 days post-surgery. The results are representative of at least three independent experiments. Lower panels are high magnification images of the squares in the upper images (remained collagen pellet *). Two-way arrows and white arrowheads indicate the bone defects and newly-formed bone, respectively.