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. 2020 Oct 27;21(21):7967. doi: 10.3390/ijms21217967

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Depletion of bone marrow cells inhibits FGF-2-induced bone formation in the marrow cavity. FGF-2-adsorbed collagen pellets were implanted in mouse femur defects in the following conditions: (#1) Intact marrow (normal, control); (#2) Ablated marrow (ablation); (#3) Femur translocation; (#4) Marrow ablation and femur translocation. (A) Sagittal section images of femur defect areas (left panel) and 3D images of the trabecular bone (right panel). (B) Quantitative evaluation of BV/TV of trabecular bone in femur defect area. (n = 4, *** p < 0.001 versus control pellet (#). One-way ANOVA/Tukey).