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. 2020 Nov 3;21(21):8226. doi: 10.3390/ijms21218226

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) The change of p66^SHC, NAD⁺, MMP, ROS, Mn-SOD (Mn Superoxide Dismutase), and cell vitality in SRT2104 treated hCMEC/D3 cells. The control group data are normalized to 100%. (B) The change of p66^SHC, NAD⁺, MMP, ROS, Mn-SOD, and cell vitality in EX527 treated hCMEC/D3 cells. The control group data are normalized to 100%. (C) The change of p66^SHC, MMP, ROS, Mn-SOD, and cell vitality in NAD⁺ supplement treated hCMEC/D3 cells. The control group data are normalized to 100%. The difference between different groups was compared by t-test (n = 6). ** p < 0.01 * p < 0.05.