Figure 5.

HJURP depletion impairs migration and invasion of colorectal cancer cell lines in vitro. Control or HJURP-siRNA colorectal cancer cell lines were seeded on a matrigel uncoated or coated Transwell, followed by incubation for 48 h for assessing migration and invasion, respectively. (A) Imaging was done using an inverted microscope and representative images are shown (× 40). (B) HJURP-siRNA cells displayed significantly reduced ability of migration (HT29; * p = 0.027, HCT116; * p = 0.023, SW480; ** p = 0.007, SW620; * p = 0.031). (C) siRNA mediated depletion of HJURP expression was suppressed the invasion ability of colorectal cancer cells (HT29; * p = 0.021, HCT116; * p = 0.028, SW480; * p = 0.011, SW620; * p = 0.026).