Table 1.
Patient characteristics, clinical and biochemical findings in relation to miR-21-5p, miR-122-5p, and miR-320a-3p at baseline.
| Variable | All (n = 179) | All Selected miRNA Below Median (n = 59) | One or More of Selected miRNA above Median (n = 120) | p-Value |
|---|---|---|---|---|
| Age, years | 66 (12) | 64 (13) | 67 (12) | 0.096 |
| Women, n (%) | 47 (26) | 11 (19) | 36 (30) | 0.105 |
| BMI, kg/m2 | 26.9 (4.2) | 26.2 (4.3) | 27.3 (4.1) | 0.101 |
| Prior MI, n (%) | 45 (25) | 14 (24) | 31 (26) | 0.757 |
| Prior CABG, n (%) | 11 (6) | 5 (9) | 6 (5) | 0.363 |
| Clinical Characteristics | ||||
| ACS etiology, n (%) | 143 (80) | 45 (76) | 98 (82) | 0.395 |
| Altered mental state at presentation, n (%) | 118 (67) | 34 (58) | 84 (71) | 0.719 |
| Oliguria, n (%) | 94 (53) | 29 (49) | 65 (56) | 0.424 |
| LVEF, % | 33 (14) | 33 (14) | 33 (14) | 0.734 |
| Biochemical Findings | ||||
| eGFR, mL/min/1.73 m2 | 63 (30) | 72 (29) | 58 (29) | 0.003 |
| hsTnT, ng/L | 2190 (388–5418) | 1473 (407–5419) | 2427 (386–5417) | 0.645 |
| NT-proBNP, ng/L | 2710 (585–9434) | 2475 (942–7487) | 2759 (563–9716) | 0.888 |
| ALT, U/L | 44 (20–92) | 21 (11–42) | 66 (29–129) | <0.001 |
| Blood lactate, mmol/L | 2.7 (1.7–5.7) | 2.1 (1.4–3.1) | 3.4 (2.1–6.7) | <0.001 |
| CRP, mg/L | 16 (4–54) | 17 (5–48) | 15 (4–60) | 0.925 |
Results are presented as numbers (n) and percentages (%), mean ± SD for normally distributed variables and median with IQR for non-normally distributed variables. BMI, body mass index; MI, myocardial infarction; CABG, coronary artery bypass grafting; ACS, acute coronary syndrome; LVEF, left ventricular ejection fraction; eGFR, estimated glomerular filtration rate; hsTnT, high-sensitivity troponin T; NT-proBNP, N-terminal fragment of pro-B-type natriuretic peptide; ALT, alanine aminotransferase; CRP, C-reactive protein.