Table 4.

Multivariable Cox regression analysis showing hazard ratios of individual miRNA levels when adjusted with the CardShock risk score variables and ALT at baseline.

Variable	Hazard Ratio (95% CI)	p-Value
miR-21-5p
miR-21-5p level above median	2.10 (1.26–3.49)	0.004
Age	1.02 (0.99–1.04)	0.183
Altered mental state	1.92 (1.01–3.65)	0.048
Previous MI or CABG	1.74 (1.05–2.87)	0.031
ACS etiology	1.52 (0.76–3.04)	0.240
LVEF	0.97 (0.95–0.99)	0.002
Lactate	1.08 (1.03–1.14)	0.001
eGFR	0.99 (0.98–1.00)	0.049
ALT	1.00 (1.00–1.00)	0.301
miR-122-5p
miR-122-5p level above median	1.33 (0.76–2.34)	0.321
Age	1.02 (0.99–1.04)	0.250
Altered mental state	1.71 (0.88–3.29)	0.111
Previous MI or CABG	1.77 (1.06–2.94)	0.028
ACS etiology	1.59 (0.78–3.23)	0.198
LVEF	0.98 (0.96–1.00)	0.014
Lactate	1.09 (1.03–1.14)	0.001
eGFR	0.99 (0.98–1.00)	0.038
ALT	1.00 (1.00–1.00)	0.481
miR-320a-3p
miR-320a-3p level above median	2.01 (1.21–3.31)	0.007
Age	1.02 (0.99–1.05)	0.140
Altered mental state	1.72 (0.91–3.27)	0.098
Previous MI or CABG	1.79 (1.08–2.97)	0.024
ACS etiology	1.48 (0.74–2.98)	0.271
LVEF	0.97 (0.95–0.99)	0.006
Lactate	1.09 (1.04–1.14)	0.001
eGFR	0.99 (0.98–1.00)	0.051
ALT	1.00 (1.00–1.00)	0.339

MI, myocardial infarction; CABG, coronary artery bypass grafting; ACS acute coronary syndrome; LVEF, left ventricular ejection fraction; eGFR, estimated glomerular filtration rate; ALT, alanine aminotransferase; CI, confidence interval.