Figure 1.

Peritubular capillary rarefaction in the kidney cortex. (A) Peritubular capillaries surround tubules in the normal kidneys. (B) Peritubular capillaries rarefy after kidney injury, leading to capillary regression. Peritubular capillary endothelial cells are visualized with immunofluorescence staining for CD31 (red). Note that many of peritubular capillaries lose their lumina in the injured kidney whereas the capillary lumen is clearly maintained in the normal kidney. Kidney injury is induced by unilateral ureteral obstruction (UUO) in the mouse. T indicates a tubular epithelial compartment. Blue represents nuclei. Scale bar, 50 μm.