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. 2020 Oct 28;25(21):4991. doi: 10.3390/molecules25214991

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Scheme 1 — Reagents and conditions: (a) (Boc)₂O, DIPEA, DCM, 83%; (b) N-Boc-p-phenylenediamine, EDCI, HOBT, DCM, 85%; (c) CF₃COOH, DCM, 95% for 17, 32% for P1; (d) suberic acid monomethyl ester, EDCI, HOBT, DMF, 80 °C, 62%; (e) 10% Pd/C, ammonium formate, MeOH, THF, 65 °C, 92%; (f) 14, EDCI, HOBT, DMF, 80 °C, 58%; (g) NH₂OK/MeOH, 65%.