Scheme 2.
Reagents and conditions: (a) 1) (Boc)2O, DIPEA, DCM, 66%; 2) 3-(methoxycarbonyl)benzoic acid, HATU, DIPEA, DMF, 88%; (b) HCl/dioxane, 11% for P2; (c) 14, HATU, DIPEA, DMF, 82%; (d) NH2OK/MeOH.
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